2022-09-05


姓名:
尹铁英
职称:
教授、博导
研究方向:
组织修复、生物力学、药物缓释
联系方式:
tieying_yin@cqu.edu.cn
工作方式:
兼职

尹铁英,重庆大学生物工程学院副教授,博士生导师。2007年6月获得重庆大学生物医学工程博士学位。曾为加拿大拉瓦尔大学外科系博士后,英国纽卡斯尔大学机械和系统工程学院访问学者。

主要从事生物医学工程与生物学科领域心脑血管生物力学、生物流变学、生物材料与组织修复,新型纳/微药物缓控释系统等方向的研究。累计发表学术论文100余篇,根据科睿唯安 (原汤森路透) Journal Citation Reports(JCR)分区,近五年发表40篇SCI期刊文章,其中JCR一区22篇(第一/通信作者15篇),包括Bioactive Materials、Nano letters、NPG Asia Materials、Advanced Science、Materials Today Bio、Journal of Controlled Release、ACS Appl Mater Interfaces、Advanced Healthcare Materials、J Nanobiotechnology、Biomaterials Science等。近年来主持和参加十二五、十三五国家科技支撑计划课题、国家发改委科学研究计划项目、国家自然科学基金重点/面上/青年基金项目、科技部国际科技合作重点项目、人事部留学人员科技活动项目择优资助项目、重庆市自然科学基金以及多项中央高校等项目。研制出系列新型组织工程植入物,获权国家专利14件,其中国际发明专利1件。相关研究成果获得重庆市科技进步一等奖一项,重庆大学科技进步一等奖一项。


论文列表

a)    排名及影响因子出处:科睿唯安(原汤森路透)Journal Citation ReportsJCRhttps://jcr.clarivate.com/JCRLandingPageAction.action“.

b)    通讯作者标注*.

[1]      Meng Yang, Bingyi Wang, Ying Yin, Xiaoyue Ma, Lin Tang, Yu Zhang, Qin Fan, Tieying Yin*, Yazhou Wang*. PTN-PTPRZ1 signaling axis blocking mediates tumor microenvironment remodeling for enhanced glioblastoma treatment. Journal of Controlled Release. In press. [SCI] 影响因子:11.467 (2021), 11.371 (5-year) (JCR一区)

[2]      Tieying Yin‡,*, Qin Fan‡, Fangfang Hu‡, Xiaoyue Ma, Ying Yin, Bingyi Wang, Lei Kuang, Xiaoye Hu,  Bo Xu,  Yazhou Wang*. Engineered Macrophage Membrane Coated Nanoparticles with Enhanced PD-1 Expression Induce Immunomodulation for a Synergistic and Targeted Anti-glioblastoma Activity. Nano letters. 2022 Aug 24;22(16):6606-6614. doi: 10.1021/acs.nanolett.2c01863. [SCI] 影响因子: 12.262 (2021), 12.709 (5-year) (JCR一区)

[3]      Junyang Huang, Shuang Ge, Desha Luo, Ruolin Du, Yang Wang, Wanling Liu, Guixue Wang*, Tieying Yin*. The Endothelium Permeability after Bioresorbable Scaffolds Implantation Caused by the Heterogeneous Expression of Tight Junction Proteins. Materials Today Bio. 2022 Aug 27;16:100410. doi: 10.1016/j.mtbio.2022.100410. [SCI] 影响因子: 10.761  (2021), 10.761 (5-year) (JCR一区)

[4]      Yang Wang, Yuhua Huang, Ruolin Du, Shuang Ge, Yanhong Li, Guixue Wang, Yazhou Wang*, Tieying Yin*. The crosstalk between arterial components and the bioresorbable, 3-D printed poly-l-lactic acid scaffolds. Biomaterials Science, 2022, 10, 5121 - 5133 doi: 10.1039/d2bm00732k. [SCI] 影响因子: 7.59 (2021), 7.699 (5-year) (JCR一区)

[5]     Junyang Huang, Kun Zhang, Ruolin Du, Wanling Liu, Haijun Zhang, Tian Tian, Yazhou Wang, Guixue Wang*, Tieying Yin*. The janus-faced role of Piezo1 in cardiovascular health under mechanical stimulation. Genes & Diseases. 2022 https://doi.org/10.1016/j.gendis.2022.08.015. [SCI] 影响因子: 7.243 (2021), 8.849(5-year) (JCR一区)

[6]       Tieying Yin#,∗, Ruolin Du#, Yang Wang#, Junyang Huang, Shuang Ge, Yuhua Huang, Youhua Tan, Qing Liu, Zhong Chen, Hanqing Feng, Jie Du, Yazhou Wang∗, Guixue Wang∗, Two-stage degradation and novel functional endothelium characteristics of a 3-D printed bioresorbable scaffold, Bioactive Materials, 2021 Aug 24;10:378-396. doi: 10.1016/j.bioactmat.2021.08.020. [SCI] 影响因子: 16.874 (2021), 17.363 (5-year) (JCR一区)

[7]      Yingchun Huang, Kun Zhang, Li Zhang, Juhui Qiu, Lin Fu, Tieying Yin, Jing Wang, Rui Qin, Jingjie Zhang, Xianwen Dong, Guixue Wang. Dosage of Dual-Protein Nutrition Differentially Impacts the Formation of Atherosclerosis in ApoE−/− Mice. Nutrients 2022 Feb 18;14(4):855. doi: 10.3390/nu14040855. [SCI] 影响因子: 6.706 (2021), 7.185(5-year) (JCR一区)

[8]      Tieying Yin∗, Yanhong Li, Yuzhen Ren, Atik Rohmana Maftuhatul Fuad, Fangfang Hu, Ruolin Du, Yang Wang, Guixue Wang, Yazhou Wang∗. Phagocytosis of polymeric nanoparticles aided activation of macrophages to increase atherosclerotic plaques in ApoE−/− mice. Journal of Nanobiotechnology. 2021 Apr 28;19(1):121. doi: 10.1186/s12951-021-00863-y. [SCI] 影响因子: 10.435 (2021), 11.509 (5-year) (JCR一区)

[9]      Yinping Zhao, Guangchao Zang, Tieying Yin, Xiaoyi Ma, Lifeng Zhou, Lingjuan Wu, Richard Daniel, Yunbing Wang, Juhui Qiu, Guixue Wang, A novel mechanism of inhibiting in-stent restenosis with arsenic trioxide drug-eluting stent: Enhancing contractile phenotype of vascular smooth muscle cells via YAP pathway. Bioactive Materials. 2020 Sep 4;6(2):375-385. doi: 10.1016/j.bioactmat.2020.08.018. [SCI] 影响因子: 16.874 (2021), 17.363 (5-year) (JCR一区)

[10]     Wenhua Yan, Tianhan Li, Tieying Yin, Zhengjun Hou, Kai Qu, Nan Wang, Colm Durkan, Lingqing Dong, Juhui Qiu, Hans Gregersen,Guixue Wang.M2 macrophage-derived exosomes promote the c-KIT phenotype of vascular smooth muscle cells during vascular tissue repair after intravascular stent implantation. Theranostics 2020, Vol. 10, Issue 23 2020; 10(23): 10712-10728. doi: 10.7150/thno.46143 [SCI] 影响因子: 11.6 (2021), 12.201(5-year) (JCR一区)

[11]     Ying Yin, Jun Wang, Meng Yang, Ruolin Du, Giuseppe Pontrelli, Sean McGinty, Guixue Wang, Tieying Yin* and Yazhou Wang. Penetration of the blood–brain barrier and the anti-tumour effect of a novel PLGA-lysoGM1/DOX micelle drug delivery system, Nanoscale, 2020 Feb 7;12(5):2946-2960. doi: 10.1039/c9nr08741a [SCI] 影响因子: 8.307 (2021), 7.891 (5-year) (JCR一区)

[12]     Yi Wang#, Hualin Lan#, TieyingYin*, Xiaojuan Zhang, Junyang Huang, Haiyang Fu, Junli Huang Sean McGinty, Hao Gao, Guixue Wang*, Zhaoxu Wang*. Covalent immobilization of biomolecules on stent materials through mussel adhesive protein coating to form biofunctional films. Materials science & engineering. C, Materials for biological applications. 2020 Jan;106:110187. doi: 10.1016/j.msec.2019.110187. [SCI] 影响因子: 8.457 (2021), 7.499 (5-year) (JCR一区)

[13]     Shuang Ge#, Yadong Xi#, Ruolin Du, Yuzhen Ren, Zichen Xu, Youhua Tan, Yazhou Wang, Tieying Yin*, Guixue Wang*. Inhibition of In-Stent Restenosis after Graphene Oxide Double-Layer Drug Coating with Good Biocompatibility. Regenerative Biomaterials. 2019 Oct;6(5):299-309. doi: 10.1093/rb/rbz010.  [SCI] 影响因子: 5.763 (2021), 6.38 (5-year) (JCR二区)

[14]     Yi Wang, Kang Zhang, Xian Qin, Tianhan Li, Juhui Qiu, Tieying Yin, Junli Huang, Sean McGinty, Giuseppe Pontrelli, Jun Ren, Qiwei Wang, Wei Wu, Guixue Wang. Biomimetic Nanotherapies: Red Blood Cell Based Core–Shell Structured Nanocomplexes for Atherosclerosis Management. Advanced Science. 2019 Apr 24;6(12):1900172. doi: 10.1002/advs.201900172. [SCI] 影响因子: 17.521 (2021), 18.939 (5-year) (JCR一区)

[15]     Ali Maruf, Yi Wang, Tieyin Yin, Junli Huang, Nan Wang, Colm Durkan, Youhua Tan, Wei Wu, Guixue Wang. Atherosclerosis Treatment with Stimuli-Responsive Nanoagents: Recent Advances and Future Perspectives. Advanced Healthcare Materials. 2019 Jun;8(11):e1900036. doi: 10.1002/adhm.201900036. [SCI] 影响因子: 11.092 (2021), 10.782 (5-year) (JCR一区)

[16]     Qilong Wang, Yuanli Liu, Jingsong Guo, Song Lin, Yeqi Wang, Tieying Yin, Hans Gregersen, Tingzhang Hu, Guixue Wang. Microcystin-LR induces angiodysplasia and vascular dysfunction through promoting cell apoptosis by the mitochondrial signaling pathway. Chemosphere. 2019 Mar;218:438-448. doi: 10.1016/j.chemosphere. [SCI] 影响因子: 8.943 (2021), 8.52 (5-year) (JCR一区)

[17]     Edwin J Bunggulawa, Wei Wang, Tieying Yin*, Nan Wang, Colm Durkan, Yazhou Wang*, Guixue Wang. Recent advancements in the use of exosomes as drug delivery systems. Journal of Nanobiotechnology. 2018 Oct 16;16(1):81-93. doi: 10.1186/s12951-018-0403-9. [SCI] 影响因子: 10.435 (2021), 11.509 (5-year) (JCR一区) ESI高被引论文

[18]     Xiaolin Ran, Zhiyi Ye, Meiling Fu, Qilong Wang, Haide Wu, Song Lin, Tieying Yin, Tingzhang Hu, Guixue Wang. Design, preparation and performance of a novel bilayer tissue-engineered small-diameter vascular graft. Macromolecular Bioscience  2018 Sep 27:e1800189. doi: 10.1002/mabi.201800189  [SCI] 影响因子: 5.859 (2021), 4.752 (5-year) (JCR一区)

[19]     Ruolin Du#, Yazhou Wang#, Yuhua Huang, Yinping Zhao, Dechuan Zhang, Dingyuan Du, Yuan Zhang, Zhenggong Li, Sean McGinty, Giuseppe Pontrelli, Tieying Yin*, Guixue Wang*. Design and testing of hydrophobic core/hydrophilic shell nano/micro particles for drug-eluting stent coating. NPG Asia Materials, volume 10, pages 642–658 (2018) doi: 10.1038/s41427-018-0064-z [SCI] 影响因子: 10.481 (2021), 10.99 (5-year) (JCR一区)

[20]     Wenjie Sun#, Yuhua Huang#, Tieying Yin*, Jingjing Wang, Ruolin Du, Juhui Qiu, Yuan Zhang,  Yazhou Wang*, Jinju Chen, Guixue Wang. Effects of elemene on inhibiting proliferation of vascular smooth muscle cells and promoting reendothelialization at the stent implantation site. Biomaterials Science, 2017 May 30;5(6):1144-1155. doi: 10.1039/c7bm00190h [SCI] 影响因子: 7.59 (2021), 7.699 (5-year) (JCR一区)


主持项目

[1]     国家自然科学基金面上项目, 低振荡切应力调控血管内皮细胞清道夫受体-B1促进动脉粥样硬化的力学生物学机制研究,12272071,2023/01–2026/12。

[2]     国家自然科学基金重点项目子课题, 血管内皮细胞通过清道夫受体吞噬脂质促动脉粥样硬化发生的细胞力学生物学机制研究,12032007,2021/01–202/12。



  授权专利

[1]       王亚洲, 邹丹, 尹铁英, 王贵学. DRUD-LOADED GANGLIOSIDE MICELLE AND THE PREPARATION METHOD AND USE THEREOF, 美国发明专利(US 10039713 B1),2018.08.07

[2]       王贵学,刘宛灵,尹铁英. 一种生物混合型人工血管及其制备方法,中国发明专利(ZL 201911054424.5),2021.08.25

[3]       王贵学, 罗力, 吴伟, 尹铁英, 刘元莉, 王溢. 生物可降解示踪材料及其制备方法和应用,中国发明专利(ZL201810498500.0),20181009

[4]       王贵学, 罗力, 吴伟, 尹铁英, 王溢. 生物可降解材料及其制备方法和应用 ,中国发明专利(ZL201810498586.7),20181012

[5]       王亚洲, 邹丹, 尹铁英, 王贵学. 载药神经节苷脂胶束及其制备方法和应用,中国发明专利(ZL201710150621.1),20170725

[6]       王贵学,叶志义,席亚东,尹铁英,董文秀. 组织工程人工血管培养实验装置, 实用新型专利(ZL 2016 2 0053703.5),  2016.08.31

[7]       王贵学,叶志义,席亚东,尹铁英,董文秀. 组织工程人工血管培养实验装置及其使用方法. 中国发明专利(ZL201610038226.X),2016.04.20

[8]       王贵学, 孙大明, 尹铁英. 血管内支架涂层制备装置.实用新型专利(ZL2013203637173),2013.11.27

[9]       王贵学, 杜若林,尹铁英,王亚洲,饶琼. 一种核壳结构纳微粒涂层血管支架及其制备方法,中国发明专利(ZL 201310350012.2),2016.01.13

[10]      王贵学,饶琼,胡廷章,尹铁英,王亚洲,杜若林.一种多层涂层药物洗脱血管支架的制备方法,中国发明专利(ZL 201310350016.0),2016.01.20



  获奖及荣誉

[1]       2020  重庆市自然科学一等奖(排名第三)

[2]       2018  重庆大学科技进步一等奖(排名第二)

[3]       2017  重庆大学自然科学三等奖(排名第三)